A method of preparing a stretchable sleeve has been patented. The method includes providing the sleeve in an outside-out configuration. The sleeve has a first open end and a second open end and the two open ends are interconnected by a passage surrounded by an interior surface of the sleeve. The sleeve includes a medicinal section adapted to be loaded with a medicinal composition and a perforated section comprising a plurality of openings. Each opening is about 0.3 mm to 3 cm in its longest dimension in a relaxed state of the sleeve. The medicinal section and the perforated section overlap when the passage of the sleeve is collapsed. The medicinal section and the perforated section are located at circumferentially opposite sides of each other. The passage of the sleeve is sized so that the interior surface of the sleeve contacts a body portion when it is inserted into the passage of the sleeve through the open ends. The process also includes collapsing the sleeve with the perforated section facing the top and the medicinal section facing the bottom and applying the medicinal composition from the top such that the medicinal composition is received on the interior surface of the medicinal section through the openings of the perforated section.